Little Boys Flannel Purpose: Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children.Despite cure rates of higher than 85 %, refractory or relapsed ALL still exhibits a bleak prognosis indicative of the dearth of treatment modalities specific for relapsed or refractory ALL.Prior research has implicated metabolic a
The carotenoids are the most widely distributed secondary metabolites in plants and can be degraded by carotenoid cleavage dioxygenase (CCD) to form apocarotenoids including an important C13 compound beta-ionone.Volatile beta-ionone can confer the violet and woody fragrance to plant essential oils, flowers, fruits, and vegetables, which therefore h
Helminth infections continue to be a neglected global threat in tropical regions, and there have been growing cases of anthelmintic resistance reported towards the existing anthelmintic drugs.Thus, the search for a novel anthelmintic agent has been increasing, especially those derived from plants.Leucaena leucocephala (LL) is a leguminous plant tha
Background Early diagnosis of head and neck cancer (HNC) will improve patient outcomes.The low incidence of HNC renders its detection challenging for a general practitioner (GP) in primary health care (PHC).Patients and methods To examine these challenges, our cohort consisted of all patients visiting PHC centres in the City of Helsinki in 2016.We
We have recently shown that chemotherapy with immunogenic cell death (ICD)-inducing agents can be advantageously combined with fasting regimens or caloric restriction mimetics (CRMs) to achieve superior tumor growth control via a T cell-dependent mechanism.Here, we show that the blockade of the CD11b-dependent extravasation of myeloid cells blocks